Initiation of apoptosis activates protelytic caspases.
1. Caspases degrade cellular organelles.
2. Caspases cleave proteins within the cytoplasm which causes the cell to shrink and creates small protrusions on the surface of the cell called blebs.
3. Caspases activate productions of DNases, which break down DNA and the nucleus that holds it.
4. Caspases create a signal that attracts macrophages to clean up the destroyed cell.